%0 Journal Article %T Exploring the Acceptability of Lay-Carer Administration of Anticipatory Injectable Medications in Home-Based End-of-Life Care %A Karolina Novak %A Tomasz Wrobel %J Journal of Integrative Nursing and Palliative Care %@ 3006-5550 %D 2026 %V 7 %N 1 %R 10.51847/4dGObKtGgN %P 64-75 %X Global data indicate that the majority of individuals prefer receiving end-of-life care and dying in their own homes, provided the care is of high quality. Nonetheless, this objective is frequently obstructed by systemic and logistical barriers. Palliate represents a nurse-guided intervention designed to overcome these obstacles. It equips lay-carers to administer end-of-life subcutaneous injections to their relatives by providing targeted training, instructional materials, and structured documentation. To examine how patients, informal caregivers, and healthcare providers perceive and experience the acceptability of the Palliate intervention via the Theoretical Framework of Acceptability (TFA), while identifying perceived obstacles and facilitators to its execution. Guided by the TFA, a qualitative investigation was executed utilizing semi-structured interviews with healthcare practitioners, patients, family carers, and policy-makers. The gathered data underwent deductive thematic analysis. Perspectives on the acceptability of this end-of-life intervention were gathered from thirty participants, comprising individuals diagnosed with advanced progressive illnesses, family caregivers, and various healthcare professionals working in palliative care. Respondents highlighted several potential advantages, such as improved symptom management, shorter delays in medication delivery, and greater empowerment of families providing home care. Conversely, apprehensions were voiced regarding caregiver burden, emotional strain, and the necessity of clinical supervision. A segment of the sample was drawn from direct practical experience in deploying or assisting with the intervention, offering valuable insights into both its functional utility and operational challenges. Although the Palliative intervention was broadly perceived as acceptable and potentially advantageous, expanding its implementation demands meticulous planning. Acceptability depended heavily on caregivers receiving structured training, continuous professional support, and participating on a purely voluntary basis. These outcomes shed light on the boundaries of informal caregiving and carry clear implications for incorporating family-led end-of-life medication management into health systems. Before recommending wider clinical adoption, additional research is required to assess its safety, outcomes, and feasibility across diverse environments. %U https://journalinpc.com/article/exploring-the-acceptability-of-lay-carer-administration-of-anticipatory-injectable-medications-in-ho-e4clwxxq650vtz7