It seems that male nurses do not pay much attention to their occupational health because of the many professional concerns including shift work tensions and longer presence in the workplace, which causes a decrease in the quality of work life, decrease in job satisfaction, and become stressed and depressed. Thus, the current study was done to specify job satisfaction and its related factors in male nurses. The current study was of descriptive and analytical type and 108 nurses were included in the research by available sampling method. The data were provided by a questionnaire consisting of two parts, demographic characteristics, and the questionnaire of Minnesota job satisfaction, and were analyzed at two descriptive and inferential levels using SPSS version 23 software. The highest age group was between 26-35 years old and the lowest age group was > 45 years old. The score of job satisfaction of male nurses was at the average level, the lowest score associated with this area was development opportunities and the highest score was job content. A significant relationship was found between body mass index and nurses' job satisfaction (P = 0.020). The exposure prevalence to occupational hazards in male nurses was mental, physical, ergonomic, and Bodily. According to the obtained results, the implementation of strategies to make positive changes in the environment, such as satisfaction with salaries and wages, and the balance between shift work and career advancement opportunities, can cause increased job satisfaction and decreased disability in male nurses.