Diabetes as a chronic disease can have bad impacts on the marital relationships of affected people. Investigating the protective factors' role in the marital satisfaction of these patients is very important. The purpose of this research was to study the sexual satisfaction mediating role in the relationship between self-care and health literacy of men with diabetes and women's marital satisfaction. The current research was of a descriptive-correlation type. To carry out the research, taking into account the inclusion criteria, the samples were selected by simple random method and completed the questionnaires. To collect data, the Enrich couple scale, sexual satisfaction questionnaire, health literacy for adults, and the summary of diabetes self-care activities were used. Data analysis was done using the path analysis method using SPSS 23 statistical software. The findings of the structural model test demonstrated that the fit indices are in a favorable condition. In addition, the findings of the path analysis revealed that the self-care of men with diabetes has a significant and positive effect on women's marital satisfaction with the mediation of sexual satisfaction. Men's health literacy has a positive impact on women's marital satisfaction with the sexual satisfaction mediating role (P < 0.01). According to the results of this study, the health literacy and self-care role of men with diabetes in women's marital satisfaction is mediated using sexual satisfaction. Based on the findings of the research, it is suggested to hold educational programs to improve the health literacy and self-care of patients with diabetes.