The sense of coherence can affect the personal and professional performance of nurses, and it is essential to identify and investigate the factors effective in it. The current study was done to study the mediating role of ambiguity tolerance in the relationship between emotion management and sense of coherence in nurses. The current study was descriptive-correlational and structural equation modeling. Among the nurses, 189 people were selected through available sampling. Data collection tools included an ambiguity tolerance questionnaire, a sense of coherence questionnaire, and an emotion regulation questionnaire. The results of the research revealed that the correlation coefficient between emotion management and ambiguity tolerance, ambiguity tolerance and sense of coherence, and emotion management and sense of coherence is significant (P < 0.05). Also, ambiguity tolerance had a mediating role in the relationship between emotion management and a sense of coherence in nurses. Based on this, in the relationship between the management of emotion and a sense of coherence in nurses, ambiguity tolerance had a mediating role. Thus, emotion management through increasing the level of ambiguity tolerance in nurses can help to strengthen the sense of coherence in them.
