End-of-life care is provided in various healthcare settings beyond specialized palliative units, underscoring the need to identify barriers and promote safe, high-quality care. This study sought to assess nurses’ attitudes toward end-of-life care and to identify both hindering and supportive factors influencing such care in multi-profile hospitals across Eastern Europe. A descriptive, correlational design was applied using a cross-sectional survey of 1,320 registered nurses from seven hospitals in Lithuania. Across all hospital types, nurses highlighted the importance of ensuring patient safety, delivering effective care, and addressing spiritual needs at the end of life. Major obstacles reported included expressions of anger from family members, relatives’ limited understanding of nursing care, lack of time for patient communication, insufficient knowledge to support bereaved families, disregard for nurses’ input, and physicians’ reluctance to discuss diagnoses while providing overly positive prognoses. Facilitating factors that improved end-of-life care included participation in relevant training, engagement in volunteer work, and active family involvement. Nurses identified patients’ spiritual needs as their top priority at the end of life. Family-related issues remain major barriers, while physician–nurse dynamics continue to significantly influence care quality.
