Mental health and perceived social support are important variables in preventing marital burnout in infertile women. The purpose of this research was to predict marital dissatisfaction based on perceived social support and mental health in infertile women. The current research was correlational. Through available sampling, 361 people were selected to participate in the study. Marital burnout, perceived social support, and general health questionnaires were used to collect data. Pearson's correlation coefficient and regression methods were used for data analysis using SPSS version 23 software. According to the results, mental health, the total score of social support, and the support component of family, friends, and important people had a significant negative correlation coefficient with marital burnout (P < 0.01). The results of the regression in predicting marital boredom through the dimensions of social support and mental health show that among the predictor variables, mental health had a significant role in predicting marital boredom (P < 0.05) and explained 21% of the variance of marital dissatisfaction (P < 0.001). According to the obtained results, perceived social support and mental health in infertile couples are related to the occurrence of marital burnout in this group.