Job burnout reduces the quality of life, functional level, and organizational commitment of nurses and increases the intention to leave the job. According to various studies, empowering employees and involving them in decision-making reduces job burnout. The present study was conducted to determine the relationship between the empowering behaviors of nursing leaders and the burnout of nurses. In this study, the participants were 165 nurses who were selected using the available method. To collect data, the empowering behaviors of the leader’s questionnaire and the Maslach job burnout questionnaire were used. Data analysis was done using Pearson's correlation coefficient and multiple linear regression in SPSS23 software. Pearson's correlation coefficients showed an inverse relationship between the scores of dimensions of the empowering behaviors of nursing leaders and the scores of emotional exhaustion and depersonalization of nurses' job burnout questionnaire (P<0.001). Also, a direct relationship between the scores of the dimensions of the empowering behaviors questionnaire of nursing leaders and individual success was seen (P<0.001). Based on the results of the present study, the empowering behaviors of the leaders in the studied hospital were average. The higher the empowering behaviors of the leaders, the more the job burnout of nurses decreases in different dimensions.