Professional participation has been proposed as a vital factor in the development of quality and safe care, but it has been addressed in a few studies. Therefore, the current study was done to investigate the relationship between professional participation and the quality of care of nurses working in intensive care units. This cross-sectional study was conducted on 310 nurses working in intensive care units. The data collection tool included the professional participation subscale from Rivaz et al.'s nursing professional practice environment questionnaire and the nursing care quality scale by Koi et al. P < 0.05 was considered as a significant level. The average score of professional participation subscale was 20.47 ± 5.04 and the average score of nursing care quality was 135.94 ± 18.20. There was a significant and direct relationship between professional participation and the quality of nursing care (P < 0.001, r = 0.62). The findings of the multivariate regression model revealed that the variable of nurses' professional participation explained the dimension of ethical behaviors (P < 0.001, β = 0.39) more than other aspects of nursing care quality, 0.39 and in total the professional participation variable predicted 52% of changes in the quality of nursing care. According to the obtained results, due to the significant direct relationship between professional participation and the quality of nursing care, it is necessary to carry out educational planning with an emphasis on the ethical values of the nursing profession to improve the ability of nurses in the field of professional participation and the quality of nursing care.