Providing family-oriented care and paying attention to the families of patients hospitalized in special care units is one of the necessities of special care units. On the other hand, resilience is one of the components of mental health that increases a person's ability to adapt positively in stressful situations. The current study aimed to determine the relationship between the needs and resilience of family members of patients admitted to special care units. The current research is a cross-sectional, descriptive, and correlational study. To collect information, demographic questionnaires, Connor and Davidson's resilience questionnaires, and questionnaires for assessing the needs of families of patients admitted to the special care department were used. Based on the findings of this research, the average score of family needs was 143.14 with a standard deviation of 21.75, which showed a high level of needs. The highest need of family members was associated with the dimension of assurance and information and the lowest need was associated with the dimension of support. The mean resilience score was 70.04 with a standard deviation of 16.89, which shows that the family members had acceptable resilience. According to the adjusted score in examining the resilience score of family members, the highest score was associated with the dimension of spirituality, and the lowest score was associated with the dimension of control. There was a direct and significant relationship between resilience and all dimensions of family needs (P < 0.05). Increasing the knowledge and awareness of nurses regarding the needs, the state of mental health, and the resilience of family members of patients hospitalized in special care units can improve resilience and reduce psychological consequences.