Because of multiple family and professional responsibilities, nurses are exposed to work-family conflict, which will have many negative consequences on their lives. Examining the factors affecting it for proper planning is one of the priorities of nursing managers. The current study was conducted to specify the relationship between happiness and self-efficacy with work-family conflict in nurses. The current study was a cross-sectional descriptive study of the correlation type and a total of 160 qualified nurses were included in the study through available sampling. To collect data, nurses' demographic information questionnaires, Scherer's general self-efficacy, Oxford happiness, and Carlson's work-family conflict were used. Data were analyzed with SPSS23 software and using descriptive and inferential statistical tests. The total mean of happiness was moderately downward, self-efficacy was moderate, and work-family conflict was moderate. The results showed that self-efficacy and happiness have a significant and inverse relationship with work-family conflict in nurses (P < 0.001). The findings of the current study revealed that nurses' self-efficacy and happiness are effective in their work-family conflict and it can be said that with the increase of nurses' happiness and self-efficacy, their work-family conflict decreases. Therefore, it is suggested that improving the happiness and self-efficacy of nurses will provide the basis for reducing the complications of their work-family conflict.
