Nurses are one of the important pillars in health care systems and providing care to patients. Therefore, the quality of their professional life has a complex relationship with the characteristics of the work environment, personal life environment, and exposure to occupational accidents. Therefore, the present study was conducted to investigate the quality of professional life of nurses and the factors affecting it by reviewing past studies. For this purpose, using the keywords of health, public health, quality of professional life, and nurses, it was investigated in Pubmed, Proquest, Google Scholar, Scopus, and Web of Science databases. The results of various studies showed that the quality of professional life of nurses is average. In some studies, the quality of nurses' professional lives has been reported as optimal. In addition, the results of the studies showed that the quality of professional life in nurses is influenced by various factors such as salary fairness, justice, job satisfaction, desire to leave the profession, high workload, increased overtime, fatigue, inappropriate rules, decision-making power, Empathic communication, and occupational stress. Considering the average level of the quality of professional life of nurses, it is necessary to pay attention to the factors affecting the quality of professional life to maintain and improve the quality of nursing care.